Evolution of Antibiotic Resistance without Antibiotic Exposure
نویسندگان
چکیده
منابع مشابه
Evolution of Antibiotic Resistance without Antibiotic Exposure
Antibiotic use is the main driver in the emergence of antibiotic resistance. Another unexplored possibility is that resistance evolves coincidentally in response to other selective pressures. We show that selection in the absence of antibiotics can coselect for decreased susceptibility to several antibiotics. Thus, genetic adaptation of bacteria to natural environments may drive resistance evol...
متن کاملEvolution of Antibiotic Resistance
Pietsch, F. 2015. Evolution of Antibiotic Resistance. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1150. 67 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9380-6. The emergence of antimicrobial resistance is a major global threat to modern medicine. The rapid dissemination of resistant pathogens and the associated loss of efficacy of many i...
متن کاملThe “ Evolution ” of Antibiotic Resistance
An increase in the frequency of antibiotic resistance in bacteria since the 1950s has been observed for all major classes of antibiotics used to treat a wide variety of respiratory illnesses, skin disorders, and sexually transmitted diseases. Is this resistance the result of bacteria evolving new genes in response to the presence of antibiotics, or are antibiotic-resistant bacteria selected for...
متن کاملOrigins and evolution of antibiotic resistance.
The massive prescription of antibiotics and their non-regulated and extensive usage has resulted in the development of extensive antibiotic resistance in microorganisms; this has been of great clinical significance. Antibiotic resistance occurs not only by mutation of microbial genes which code for antibiotic uptake into cells or the binding sites for antibiotics, but mostly by the acquisition ...
متن کاملEvolution and ecology of antibiotic resistance genes.
A new perspective on the topic of antibiotic resistance is beginning to emerge based on a broader evolutionary and ecological understanding rather than from the traditional boundaries of clinical research of antibiotic-resistant bacterial pathogens. Phylogenetic insights into the evolution and diversity of several antibiotic resistance genes suggest that at least some of these genes have a long...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2017
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01495-17